EPHX2 and Hypertension: Increased sEH activity in SHR was reported to contribute to the development of hypertension (Fornage et al., 2002), and SHR were shown to have elevated sEH mRNA and protein level in the kidney cortex compared to WKY (Koeners et al., 2011), which results in increased conversion of EETs to inactive metabolites, at least in the kidney.