Due to chronic overexpression of human angiotensinogen and renin, the mouse model used in this study of preeclampsia superimposed on chronic hypertension, is not only hypertensive during gestation, with a slight increase in BP from D15 to D18, but is chronically hypertensive as shown by elevated mean BP prior to pregnancy (baseline) and continued elevated BP levels when measured PP (Figure 1A). The gene discussed is REN; the disease is preeclampsia.