The heterogeneous clinical manifestations in COVID-19 may be attributed to individual variation in expression not only of ACE2 and TMPRSS2 receptors, but also of genes related to inflammation and immune responses (Elhabyan et al., 2020; Ellinghaus et al., 2020; Russo et al., 2020; Zhao J. et al., 2020). This evidence concerns the gene ACE2 and COVID-19.