IL6 and cancer: The prevailing belief is that the progression of cachexia is the result of tumor-induced immune cell activation leading to systemic inflammation and the release of potent cytokines TNFα, IFNγ, IL-1, and IL-6, which promote changes in metabolism, energy wasting, cancer-induced anorexia, and skeletal muscle protein catabolism (Dwarkasing et al., 2016; Van Norren et al., 2017).