Most studies indicate that PGC-1α protein is significantly reduced with cancer cachexia, while genome-wide transcriptome datasets show that PGC-1β gene expression is similarly diminished (Fontes-Oliveira et al., 2013; Puppa et al., 2014; Sheng et al., 2017; Van Der Ende et al., 2018). Here, PPARGC1A is linked to cancer.