Resveratrol also inhibited the activation of NLRP3 inflammasome in liver of diet-induced obesity mice, reducing IL-1, IL-6, and TNF-α production (Yang and Lim, 2014), as well as, reduced NF-kb signaling and IL-6 expression in adipose tissue of monkeys fed with high caloric diet (Jimenez-Gomez et al., 2013). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.