Similar profile was observed in aged kidneys and was associated with improvement in oxidative stress, inflammation, and renal fibrosis (Jang et al., 2018), suggesting that polyphenols could increase ACE2 expression in aged subjects and that these alterations in the ACE2/Angiotensin- (1–7)/MasR axis have beneficial results. This evidence concerns the gene ACE2 and renal fibrosis.