AdipoQ-deficient mice possess a variety of clinical features in the AD brain, such as decreased concentrations of synaptic proteins, insulin resistance, and the existence of neuroinflammatory markers including astrogliosis, microgliosis, and higher concentrations of the inflammatory cytokines such as IL-1β and TNFα (Ng et al., 2016). The gene discussed is IL1B; the disease is Alzheimer disease.