The brain of AD patients exerts a prolonged state of low-level inflammation, which is induced by the activation of microglial cells that leads to the secretion of several inflammatory cytokines such as interleukin (IL)-6, tumor necrosis factor-α (TNFα), and IL-1β (Bamberger et al., 2003; Lourenco et al., 2013; Heneka et al., 2015; Hansen et al., 2018; Uddin et al., 2020b). This evidence concerns the gene TNF and Alzheimer disease.