The above interpretations were again validated by another analysis showing that gene-therapy mediated AdipoQR1 suppression further induces AD-like pathogenesis, which comprises dysfunction in the spatial memory as well as learning, insulin signaling deficiency, elevated concentrations of Aβ accretions and hyperphosphorylated tau, neuroinflammation as well as other neurodegenerative events (Kim et al., 2017). This evidence concerns the gene INS and Alzheimer disease.