Other studies suggested that insulin resistance (Capurso and Capurso, 2012; Johnson and Olefsky, 2013; Medina-Urrutia et al., 2015) is associated with an excess of adiposity induced by high free fatty acid (Perseghin et al., 2003) and lower levels of plasma AdipoQ (Arita et al., 2012). The gene discussed is ADIPOQ; the disease is Insulin resistance.