Rituximab is a monoclonal antibody that depletes B cell population by targeting their CD20 surface antigen, showing up to 20% improvement in RA symptoms (Edwards et al., 2004), while Tocilizumab, an anti-IL-6 monoclonal antibody demonstrated a decrease in bone degradation markers when combined with methotrexate (Garnero et al., 2010). The gene discussed is IL6; the disease is rheumatoid arthritis.