Figures 2G–I show that caspase-1 co-localized with GSDMD or NLRP3 mainly in the tubules, and colocalization was significantly higher in DKD rats compared with the controls. However, in TSF-treated rats, colocalization of pyroptotic-related proteins was effectively inhibited. Original pictures of Figure 2G were uploaded to the Supplementary Materials. Here, CASP1 is linked to diabetic kidney disease.