KCNJ11 and Parkinson disease: We previously reported that kir6.2 deficiency protected against dopaminergic neurodegeneration in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model (Zhang et al., 2018b; Zhou et al., 2018), implying that the kir6.2-KATP channel is a potential pathological target for metabolic stress in PD.