KCNJ11 and Parkinson disease: We have shown in previous studies that kir6.2 deletion and kir6.2-composing KATP channel inhibition alleviated the neurotoxin-induced PD pathology; such improvement verifies the critical roles of kir6.2-KATP channel in metabolic stress of PD (Zhang et al., 2018b; Zhou et al., 2018).