Although multiple evidences revealed that autophagy regulates NLRP3 inflammasome thus mitigating inflammatory response (Han et al., 2019; Houtman et al., 2019; Mehto et al., 2019; Fei et al., 2020), although the underlying mechanism of how autophagy affects the activation of NLRP3 inflammasome in PD is not completely understood. The gene discussed is NLRP3; the disease is Parkinson disease.