As a result, the activation of NLRP3 inflammasome releases cleaved CASP1 and also cleaves pro-IL1B and pro-IL18 into mature IL1B and mature IL18, triggering inflammatory cascades (Wang et al., 2019) and causing synuclein alpha (SNCA) aggregation in PD (Wang et al., 2016). This evidence concerns the gene CASP1 and Parkinson disease.