AKT1 and neoplasm: It has to also be noted that the physiological role of P2 receptors depends on the cell type they are expressed on—inhibiting P2Y12 receptors with ticagrelor in pancreatic ductal adenocarcinoma cells decreases their proliferative capacity through the Akt pathway (Elaskalani et al., 2020), inhibition of the same receptors on macrophages enhances their tumor cell phagocytic properties involving ER stress pathway (Pavlovic et al., 2020) and inhibits the formation of inflammasome (Huang et al., 2020), whose role in cancer progression continues to be sought (Hamarsheh and Zeiser, 2020).