HMOX1 and Parkinson disease: Another study in a cell model of PD revealed that a compound isolated from G. elata Blume had neuroprotective effects by reducing apoptosis and oxidative stress via activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/anti-oxidant response element (ARE)/heme oxygenase-1 (HO-1) signaling pathway (Huang et al., 2016).