Furthermore, activation of α7 nAChRs attenuates inflammatory pain, postoperative pain, neuropathic pain, and bone cancer pain (Bagdas et al., 2011; Kiguchi et al., 2012; Gong et al., 2015; Bagdas et al., 2016; Ji et al., 2019; Sun et al., 2019). The gene discussed is CHRNA7; the disease is bone neoplasm.