Particularly, our previous studies also revealed that the spinal microglial IL-10/β-endorphin pathway in bone cancer pain and neuropathic pain mediated the α7 nAChR agonists PHA-543613-, cinobufagin- and lemairamin-induced antinociception, although their chemical structures were different (Apryani et al., 2020; Wang et al., 2020). This evidence concerns the gene IL10 and bone neoplasm.