Increased activity of Akt is observed in Alzheimer's disease brain tissues, resulting in an increase in the phosphorylation of the downstream proteins GSK3β(Ser9) (inhibits activity), Tau(Ser214) and mTor(Ser2448) (Pei et al., 2003; Griffin et al., 2005). The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.