SERPINF1 and age-related macular degeneration: Machalinska et al. reported a marked decrease in the Pigment Epithelium-Derived Factor (PEDF) plasma levels in patients with dry AMD, whereas a significant higher level of PEDF and Vascular Endothelial Growth Factor (VEGF) was observed in the wet form, suggesting that different manifestations of AMD may be the result of altered concentrations of counterbalancing stimulators/inhibitors of angiogenesis (Machalińska et al., 2012).