HIF1A and pemphigus foliaceus: Although hypoxia is a significant pathological feature of PF (Senavirathna et al., 2018)—for example, the nuclear HIF-1α protein is involved in hypoxia-induced EMT (Senavirathna et al., 2018)—several key protein targets for cellular hypoxia as well as oxidative stress did not appear in the PPI results.