Herein, we summarize the role and perspective of antidiabetic agents, mainly including insulin, metformin, pioglitazone, dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and glucagon-like peptide 1 receptor agonists (GLP-1RAs) in DM patients with coronavirus infection. Here, INS is linked to diabetes mellitus.