However, in cervical carcinoma, pancreatic cancer, high-grade gliomas, and psoriasis, overexpressed fibulin-3 was shown to upregulate VEGF expression and induce angiogenesis (Seeliger et al., 2009; Song et al., 2011; Nandhu et al., 2014; Wang et al., 2019). This evidence concerns the gene EFEMP1 and central nervous system cancer.