According to our study, those using sleeping pills usually had underlying comorbidities (e.g., concomitant hepatic disease or CHF), which may contribute to the risk of nephrotoxicity in patients with advancing age, volume depletion, and selected high-risk therapies such as NSAIDs, aminoglycosides, ACE inhibitors, and radiographic contrast media (Ponticelli et al., 2015). This evidence concerns the gene ACE and congestive heart failure.