TREM2 and Alzheimer disease: The AD mouse model 5XFAD showed greater hippocampus expression of both Chil1 and Trem2 than WT mouse siblings, as shown in Figure 3B [t(6) = 7.39, p < 0.001, for Chil1 and t(6) = 7.39, p < 0.001 for Trem2].