In a study by Pritchard et al., it was found that there was a reduction in the number of CD4+ CD25+ T cells in GBS patients in the first 1–2 weeks of the disease compared with healthy controls; no differences were seen in the numbers of total B cells, CD5+ B cells, memory B cells, γδ T cells, natural killer cells, or CD16+ natural killer T cells (Pritchard et al., 2007). Here, CD4 is linked to Guillain-Barre syndrome.