In terms of mechanisms, Liang et al. isolated PBMCs from GBS patients and controls and examined mRNA expression of T cell immunoglobulin and mucin-3 (TIM-3), which is highly expressed on Th1 cells and is thought to decrease IFN-γ secretion when bound (Liang et al., 2012). Here, IFNG is linked to Guillain-Barre syndrome.