HSPA8 and Alzheimer disease: Most of these 24 genes have been reported to be associated with AD, such as low-density lipoprotein receptor (LDLR) overexpression which increases β-amyloid clearance and decreases amyloid deposition (Krishnan et al., 2020), HSPA8 is downregulated in multiple brain regions in AD (Silva et al., 2014), and SLC9A6 mutation causes intellectual disability (Garbern et al., 2010).