Aerobic exercise increased hippocampal BDNF expression, restored the overexpression of full-length TrkB and truncated-TrkB isoforms to control levels, and altered the hippocampal activation of some proteins linked to BDNF-TrkB intracellular signaling (de Almeida et al., 2018) and resistance exercise restored to control levels the altered BDNF levels and ERK and mTOR activation in rats with epilepsy (de Almeida et al., 2017). This evidence concerns the gene NTRK2 and epilepsy.