In animal cerebral infarction models, it has also been demonstrated the neuroprotection of a variety of HDAC inhibitors, by effectively inhibiting the secondary damage due to inflammatory response and apoptotic pathways, thereby reducing the scope of stroke and improving the resultant neurological deficits (Kim et al., 2007; Langley et al., 2009; Aune et al., 2015; Ganai et al., 2016; Park and Sohrabji, 2016). This evidence concerns the gene HDAC9 and brain infarction.