Moreover, as per our findings, ischemia led to an increase in the HDAC9 expression in the brain of wild type mice, while the loss of HDAC9 was observed to suppress the release of IL-1β, IL-6, IL-18, and TNF-α in the mouse cortex, hippocampus, and hypothalamus after I/R injury (Lu et al., 2018). The gene discussed is TNF; the disease is ischemia.