The possible involvement of histone deacetylase 9 (HDAC9) in cerebral infarction has not been thoroughly studied, although recent genomic correlation studies have found that HDAC9 variant genes may be closely related to the outcome of aortic stroke (Azghandi et al., 2015; Qingxu et al., 2016), suggesting that HDAC9 may also be involved in the pathophysiology of ischemic cerebral infarction. The gene discussed is HDAC9; the disease is brain infarction.