Moreover, as reported in a previous study (Ge et al., 2019), overexpression of the single transcription factor NeuroD1 in the brain of Alzheimer’s disease model mice can directly transform the stress-involved glial cells caused by brain injury into functional neurons in situ, which were further used for gene therapy to restore the brain function in the mouse model of cerebral ischemia. Here, NEUROD1 is linked to Alzheimer disease.