As a Cl− transporter, NKCC1 plays an important role in neuropathic pain (Modol et al., 2014; Yousuf and Kerr, 2016; Yousuf et al., 2017; Li C. et al., 2019) and bone cancer pain (Gao et al., 2019). This evidence concerns the gene SLC12A2 and bone neoplasm.