SCN1A and Dravet syndrome: This makes our model useful for long-term studies in this disease, in particular for exploring the comorbidities associated with DS, which cannot be investigated in models based on complete deletion of Scn1a gene due to premature mortality [they die before 2 weeks of age (Ogiwara et al., 2007)], and can only be partially studied in models based on heterozygous deletion, which, although present delayed mortality, reach elevated rates (they die at 3–12 weeks of age, having only a 20% of long-term survival) at the ages more adequate for investigating long-term comorbidities (Yu et al., 2006).