TNF and Dravet syndrome: Our data revealed a significant increase in CB2 receptors, an important element of the endocannabinoid system that has been related to inflammatory responses (Fernández-Ruiz et al., 2007), which was paralleled by increases in some cytokines (e.g., TNF-α, IL-1β), in the PPAR-γ nuclear receptor, and in the marker of lymphocyte activation Cd70 (Rubio et al., 2016), supporting the idea that inflammation could have an important influence in DS pathogenesis and, in general, in drug-resistant infantile epilepsies (Boer et al., 2010; Iyer et al., 2010; Koh, 2018).