Such ALS genes play roles in glutamate-mediated neurotransmission and excitability (ITPR2 and UNC13A; Varoqueaux et al., 2005; Gambardella et al., 2020), regulation of neuronal excitability (DPP6;Lin et al., 2018), autophagy (TBK1;Duan et al., 2019), cytoskeletal organization (TUBA4A;Smith et al., 2014), and axonal transport (KIF5A; Nicolas et al., 2018). The gene discussed is TUBA4A; the disease is amyotrophic lateral sclerosis.