As such, the field has made significant strides in applying RVAS using large, international collaborations (Smith et al., 2014; van Rheenen et al., 2016; Nicolas et al., 2018), the most recent of which identified KIF5A as a Mendelian ALS gene (Nicolas et al., 2018). The gene discussed is KIF5A; the disease is amyotrophic lateral sclerosis.