To further confirm whether olanzapine-induced activation of astrocytes and TLR4 signaling were related to ER stress signaling and cause weight gain, we have used an olanzapine-induced weight gain rat model (rats had ad libitum access to food) and examined whether an ER stress inhibitor could reduce olanzapine-induced food intake, weight gain, and astrocyte activation. The gene discussed is TLR4; the disease is psychosocial stress measurement.