According to these findings, values of circulating Lp-PLA2 > 138 μg/L correlate to worse FMD values [b = − 0.45 (95% CI: − 0.79 – -0.11), P = 0.01] when compared to the lowest tertile, independently of factors such as gender, age, diabetes mellitus, arterial hypertension, dyslipidemia, smoking, family history of CAD or previous myocardial infarction, serum glucose, circulating total cholesterol and LDL levels, duration of CAD, antihypertensive medication, antidiabetic drugs, statin therapy and treatment with β-blockers. The gene discussed is PLA2G7; the disease is diabetes mellitus.