CTSB and infection: The mechanism of infection is similar in both SARS-CoV-1 and SARS-CoV-2 and occurs via virus binding to protein ACE2 [9] and the intervention of the TMPRSS2 protease and, at lesser extent, of cathepsin B (CTSB) and L (CTSL) [10], which are widely distributed in human body, with a relevant expression in endocrine tissues including testicle, thyroid, adrenal and pituitary [11, 12].