Unlike some previous studies that have suggested BAG1 may be associated with a poor clinical features [16, 17], we found that its expression as a continuous variable showed a significant inverse correlation with the clinical characteristics in KIRC, such as stage (stage I vs. stage IV p < 0.001), tumor size (p < 0.001), Sex (p < 0.001), grade (p < 0.001), serum hemoglobin level (p = 0.018), cancer status (p < 0.01), lymph node metastasis (p = 0.04) and distant metastasis (p < 0.001) (Fig. 2a-i). The gene discussed is BAG1; the disease is metastatic malignant neoplasm in the lymph nodes.