Additionally, circulating PCSK9 concentration has also been proposed to be a novel biomarker for predicting the coronary artery calcification, coronary severity and worse cardiovascular outcomes in different clinical settings including general population, subjects with stable coronary artery disease (CAD), patients with familial hypercholesterolemia, and individuals with arterial fibrillation [2]. This evidence concerns the gene PCSK9 and coronary artery disorder.