Whether these represent distal regulatory elements remains to be determined but top differentially methylated regions contained potential biologically relevant genes including HLA complex group 26 (HCG26, which lies adjacent to the HLA complex P5 and between the MICA and MICB, all of which are associated with genetic risk to PsA and autoimmune diseases including SLE, RA, and type I diabetes) and Integrin Subunit β2 (ITGB2) in PsA probands [103]. This evidence concerns the gene ITGB2 and rheumatoid arthritis.