Furthermore, based on GSE28735 data set, our study demonstrated that the expression of eight among the eleven differentially expressed S100A family members in PC tissues was up‐regulated compared with those in the adjacent non‐tumour tissues, including S100A2, S100A4, S100A6, S100A10, S100A11, S100A13, S100A14 and S100A16 (Figure 2). The gene discussed is S100A16; the disease is pachyonychia congenita.