CDH2 and Neurodevelopmental delay: For instance, when no compelling variants were found in phenotypically prioritized genes in two patients presenting with muscular and white matter abnormalities, a genetics-driven UDN pipeline uncovered diagnostic de novo missense variants in both individuals in TOMM70, a gene previously unassociated with disease.37 Similarly, sequencing analyses were able to uncover de novo, heterozygous variants in nine individuals with neurodevelopmental delay and other multisystem anomalies in CDH2, a gene previously unassociated with a Mendelian neurodevelopmental condition.38