Supplementary Figures S2b and S2c show that TS genes GPC3, KLK10, KCNRG, RHOB, STARD13, CDKN1C, LATS2, RAP1A, FOXP1, TBRG1, PIK3CA and DCC were significantly lower expressed in the tumor samples than in the normal samples at stages 2 and 3. This evidence concerns the gene PIK3CA and neoplasm.