Two cases involved noncoding regions of chromosome 2 adjacent to ZFP36L2, a gene encoding an RNA binding protein that is highly expressed in hematopoietic cells and is involved in hematopoiesis, and the other involved noncoding regions of chromosome 17 adjacent to MSI2, another gene encoding an RNA binding protein that has been found to be recurrently rearranged in hematological malignancies (Fig. 3d)43–47. This evidence concerns the gene MSI2 and hematologic disorder.