SLC3A2 and diffuse intrinsic pontine glioma: Given the heterogeneity of DIPG/HGG tumors46 and the fact that SLC3A2 over-expression is independent of K27M status, is suggesting that this polyamine depleting strategy could potentially be applicable across a broad spectrum of pediatric HGG including thalamic gliomas although further studies are needed to confirm sensitivity to polyamine depletion therapy.