TOX and Autoimmunity: To elucidate the molecular mechanism by which TOX controls the presence of TCF-1-expressing cells during CNS autoimmunity, we interrogated our ATAC-seq data by evaluating the changes in the expression of genes that were found proximal to regions that became more or less accessible in the absence of TOX (Fig. 6c and Supplementary data 10: Gene expression changes associated with TCF-1 binding in ATAC-seq clusters identified in Fig. 4d).