The analysis of genes adjacent to ChARs within module A (early opening in autoimmunity) identified the genes encoding for the inhibitory receptors PD-1 and LAG-3, as well as the TFs BATF and TOX2, four previously described exhaustion-associated loci that are epigenetically remodeled15,30 (Fig. 1e, Supplementary Fig. 1f and Supplementary data 2: ATAC-seq clustering of VE, AE, VL, and AL). The gene discussed is LAG3; the disease is Autoimmunity.