TF motif enrichment analysis with HOMER confirmed the depletion of HMG-box motifs including Tcf3, Tcf4, and Tcf7 in Tox−/− P14 in module I, II, and to a lesser extent in module III, suggesting that TOX influences direct or indirect TCF-1-related epigenetic events during autoimmunity (Fig. 4h and Supplementary data 8: TF binding motifs identification in clusters identified in Fig. 4d). This evidence concerns the gene TCF3 and Autoimmunity.