The negative pleiotropy was at least partly attributable to two oral cavity/pharyngeal PRS variants (rs467095 and rs10462706; Supplementary Data 4 and Supplementary Table 2), both expression quantitative trait loci for TERT and CLPTM1L, which were inversely associated with lung cancer risk and in LD (r2 = 0.96 and 0.66, respectively) with variants in the lung cancer PRS. The gene discussed is CLPTM1L; the disease is lung cancer.