TP53 and glioblastoma: S10A–B). Consistently, 12-HETE and 12-KETE secreted from U87 GBM cells transfected with siALOXE3 were up- and down-regulated, respectively (Figure. S10C-D). In addition, U87 GBM cells transfected with siALOXE3 were resistant to p53-mediated ferroptosis and enhanced migration in a 12-HETE dependent manner (Figure. S14A–E).