Taken together, this study validated that low-dose DB sensitized CR-GC cells to cisplatin through regulating the tumor intrinsic PD-L1/NLRP3 mediated pyroptosis and CSCs properties, and provided evidences to support that low-dose DB was a novel strategy to treat GC by combining with traditional chemotherapeutic drugs in clinic. Here, NLRP3 is linked to gastric cancer.