In addition, the mice tumor tissues were collected and prepared, and our following results indicated that the expression levels of Cyclin D1 and CDK2 (P < 0.05, Fig. 1i, j), and Ki67 (Additional file 1: Figure S1) were decreased, while Caspase-3 and Bax were increased (P < 0.05, Fig. 1k, l) by co-treating CR-GC cells with DB and cisplatin. The gene discussed is CASP3; the disease is neoplasm.