Further experiments were performed to uncover the detailed mechanisms, and we found that low-dose DB combined with cisplatin increased the expression levels of pyroptosis signatures (NLRP3, ASC, IL-1β and IL-18) (P < 0.05, Fig. 2f, g) and apoptosis (cleaved Caspase-3 and Bax) (P < 0.05, Fig. 2h, i) in CR-GC cells. The gene discussed is IL1B; the disease is gastric cancer.