Also, cisplatin-DB co-treatment increased NLRP3, ASC, IL-1β, IL-18, cleaved caspase-1 and N-Gasdermin D expression levels to promote cell pyroptosis in CR-GC cells, suggesting that low-dose DB triggered both pyroptotic and apoptotic cell death in cisplatin treated CR-GC cells. This evidence concerns the gene IL18 and gastric cancer.