CD274 and neoplasm: In addition, the above cellular results were validated by the following in vivo results, and the results showed that overexpression of PD-L1 increased Cyclin D1 and CDK2 expression levels, while inhibited cleaved Caspase-3 and Bax expressions in the tumor tissues collected from xenograft mice administered with DB-Cisplatin combined treatment (P < 0.05, Fig. 6j–m).