We eagerly await the efficacy results of two trials combining erdafitinib, palbociclib, and fulvestrant (NCT03238196) and rogaratinib, palbociclib, and fulvestrant (NCT04483505) in advanced, hormonopositive, FGFR1-amplified breast cancer, which will also help to better understand the correlation between higher amplification rates of FGFR1 and rogaratinib/erdafitinib efficacy. The gene discussed is FGFR1; the disease is breast cancer.