It is in this context that we set out to determine whether the putative anti-ischaemic properties of GLP-1 could translate into an anti-anginal action during sequential exercise stress testing and in so doing demonstrate whether chronic GLP-1 receptor activation could reproduce the beneficial sequelae of the warm-up angina effect without the patient first having to perform symptom-limiting, ischaemia-provoking exercise. This evidence concerns the gene GLP1R and angina pectoris.