Due to the evidence that PvRMC-MSP1 can capture IgG from naturally exposed individuals, this study evaluates the ability of PvRMC-MSP1 to induce antibodies that bind to non-vivax-specific antigenic targets and the ability of PvRMC-MSP1 to capture naturally acquired IgG antibodies from exposed individuals with known infection status from all four human Plasmodium species. The gene discussed is ATAD1; the disease is infection.