To determine if PvRMC-MSP1 could serve as a serological tool for assessing malaria exposure, sera or purified IgG derived from rabbits and mice previously immunized with PvRMC-MSP1 was used to measure the antibody binding capacity to the immunogen or the recombinant MSP1 proteins derived from the four human Plasmodium species. The gene discussed is ATAD1; the disease is malaria.