The top 10 KEGG pathways of the DEGs showed that most DEGs were significantly enriched in tumor pathogenesis signaling pathways, such as the intestinal immune network for IgA production, extracellular matrix-receptor interactions, the AGE-RAGE signaling pathway in diabetic complications, focal adhesions, and the PI3K-Akt signaling pathway (Fig. 3g). Here, RENBP is linked to neoplasm.