CD4 and cholangiocarcinoma: The changes in the pro-inflammatory (IL2, IL4, IL6, IL17A, TNFα, and IFNγ) and anti-inflammatory (IL10) cytokine profiles, lymphocyte subpopulations, i.e., B lymphocytes, CD8+ cytotoxic T lymphocytes, CD4+ T-helper lymphocytes, and NK (natural killer) cells, and cytotoxic activity against CCA cell line, of peripheral blood mononuclear cells (PBMCs) from healthy subjects following the administration of a single and multiple dose regimens of the capsule formulation of the standardized AL extract were investigated.