Our results revealed that there were no significant associations between the ACE I/D polymorphism and lung cancer in the II vs. ID + DD (OR = 1.22, 95% CI = 0.89–1.68, P = 0.22), II + ID vs. DD (OR = 1.21, 95% CI = 0.90–1.63, P = 0.21), and I vs. D (OR = 1.15, 95% CI = 0.95–1.39, P = 0.15). Here, ACE is linked to lung cancer.