As MMP-9 is an inducible gelatinase and rs3918242 C > T in the promoter region of the gene is known to augment expression of MMP-9, these data may support the use of MMP-9 as a biomarker of ventricular dysfunction and the investigation of MMP-9 inhibitors for HF prevention in diabetes, particularly in the post-infarction setting. Here, MMP9 is linked to hydrops fetalis.