Loss of TIMP-3 in mice leads to dysregulated TNF release and subsequent increase of MMP and ADAMTS activity, thereby promoting increased cartilage breakdown in both models of inflammatory and surgically-induced arthritis [84,85], while articular injection of TIMP-3 ameliorated the pathology in a rat meniscal tear model of osteoarthritis [86]. Here, TIMP3 is linked to arthritic joint disease.