Even though compound 10 did not suppress the shedding of some cell-surface proteins (such as FKN and CXCL16 in A549 cell line and TGFα in A549), it was able to prevent the shedding of different substrates such as EGFR ligands (heregulin in A549 cells), receptors (discoidin receptor 1 (DDR1) in HCC1806 breast cancer cells and protein kinase 7 (PTK7) in human fibrosarcoma cell lines HT1080 and L622D) and cytokines (TNF in THP1 cells and IL-8 in human tracheal smooth muscle cell HTSMC) in different cell models. Here, TGFA is linked to breast carcinoma.