TIMP3 and osteoarthritis: Ultimately, the overexpression of -1Ala-TIMP-3 ameliorates the pathology in a mouse model of osteoarthritis, not only compared to wild-type controls, but also to TIMP-3 overexpressing mice, suggesting that a specific inhibition of TACE and aggrecanases over other metalloproteases is highly desirable for development of therapies [210].