Mice with systemic deletion of ADAM17 (Adam17flox/floxMx1-Cre knock-in mice, in which temporal systemic deletion of ADAM17 is obtained by injection of plpC–polyinosinic polycytidylic acid) developed more severe dextran sulfate sodium-induced colitis when compared to control littermates [128]. This evidence concerns the gene ADAM17 and colitis.